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Phase 3Data readout

Eplontersen (AKCEA-TTR-LRx)

Diabetic cardiomyopathy, Transthyretin amyloidosis, Transthyretin Amyloid Cardiomyopathy

IONSIonis Pharmaceuticals
Expected catalystAugust 28, 2026Company guidance: Aug 28, 2026

Catalyst overview

Event details

Drug or asset
Eplontersen (AKCEA-TTR-LRx)
Development stage
Phase 3
Event type
Data readout
Indication
Diabetic cardiomyopathy, Transthyretin amyloidosis, Transthyretin Amyloid Cardiomyopathy

Research summary

What is being tracked?

This catalyst tracks a Phase 3 data readout for Eplontersen (AKCEA-TTR-LRx) in Diabetic cardiomyopathy, Transthyretin amyloidosis, Transthyretin Amyloid Cardiomyopathy. The expected timing is based on the latest available company guidance and may change.

Development notes

CARDIO-TTRansform. Partnered with AstraZeneca. Phase 3 full enrollment 7/31/2023, data in 2026. 01/11/26:- CARDIO-TTRansform Ph3 ATTR-CM results expected in H2 2026; sNDA submission planned afterward. 07/08/26:- CARDIO-TTRansform missed primary endpoint; monotherapy subgroup nominal benefit. Full dataset to be presented at ESC Aug 2026. 08/20/26:- CARDIO-TTRansform Phase 3 analyses to present at ESC 2026 Aug 28.

Verification

Primary source

Confirm timing and program details against the company announcement or filing.

Open source

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Company

Ionis Pharmaceuticals

IONS · NasdaqGS
Industry
Biotechnology
Pipeline assets
25
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Updated Aug 23, 2026. Dates can change; this is not investment advice.

Disclaimer: Biotech Stock Intel is an independent research platform. Information is provided for informational purposes only and is not investment or medical advice. Always verify catalyst dates against primary sources and conduct your own research.
Biotech Stock Intel© 2026 Biotech Stock Intel
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